منابع مشابه
Systems biology in vaccine design
Vaccines are the most effective tools to prevent infectious diseases and to minimize their impact on humans or animals. Despite the successful development of vaccines that are able to elicit potent and protective immune responses, the majority of vaccines have been so far developed empirically and mechanistic events leading to protective immune responses are often poorly understood. This hamper...
متن کاملSystems biology: experimental design.
Experimental design has a long tradition in statistics, engineering and life sciences, dating back to the beginning of the last century when optimal designs for industrial and agricultural trials were considered. In cell biology, the use of mathematical modeling approaches raises new demands on experimental planning. A maximum informative investigation of the dynamic behavior of cellular system...
متن کاملSystems Biology Approach for Cancer Vaccine Development and Evaluation
Therapeutic cancer vaccines do not hold promise yet as an effective anti-cancer treatment. Lack of efficacy or poor clinical outcomes are due to several antigenic and immunological aspects that need to be addressed in order to reverse such trends and significantly improve cancer vaccines' efficacy. The newly developed high throughput technologies and computational tools are instrumental to this...
متن کاملSystems Biology-Based Approaches Applied to Vaccine Development
Vaccines represent one of the most cost-effective ways to prevent and treat diseases. The use of vaccines in the control of viral diseases represents an important milestone in the history of medicine. The genomic revolution brought us the possibility to scan genomes in the search of new and more effective vaccine candidates and the advancement of bioinformatics provided the framework for the ap...
متن کاملComparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development
Developing vaccines to biothreat agents presents a number of challenges for discovery, preclinical development, and licensure. The need for high containment to work with live agents limits the amount and types of research that can be done using complete pathogens, and small markets reduce potential returns for industry. However, a number of tools, from comparative pathogenesis of viral strains ...
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ژورنال
عنوان ژورنال: Microbial Biotechnology
سال: 2011
ISSN: 1751-7915
DOI: 10.1111/j.1751-7915.2011.00321.x